Label-free bioaffinity detection using terahertz technology
نویسندگان
چکیده
منابع مشابه
Label-free bioaffinity detection using terahertz technology.
We report the first use of differential terahertz time-domain spectroscopy for bioaffinity sensing. Binding is observed by measuring the transmission of a thin layer of biotin bound to the sensor protein avidin. We demonstrate the THz wave transmission of a sub-micron-thick film and sensitivity to 0.1 microg cm(-2) of biotin. These results point the way for a host of biosensor applications usin...
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A new affinity biosensor based on pulsed terahertz (THz) wave technology has been used to monitor binding between biotin and avidin molecules. Amplified detection of avidin-biotin binding is obtained on supported membranes composed of biotin layers on quartz surface, which is modified with octadecanol. Agarose particles are conjugated with avidin and then applied to biotin, which is already bou...
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متن کاملAmplified detection of avidin-biotin binding using terahertz wave technology
A new affinity biosensor based on a novel terahertz (THz) wave technology, differential time domain terahertz spectroscopy (DTDS), has been used to monitor the binding between biotin and avidin molecules. Amplified detection of ligandreceptor binding on supported membranes composed of a biotin bilayer on quartz modified octadecanol surface is a useful model lipid membrane for studying avidinbio...
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ژورنال
عنوان ژورنال: Physics in Medicine and Biology
سال: 2002
ISSN: 0031-9155
DOI: 10.1088/0031-9155/47/21/317